Molecular Biology Of Rna

Author: David Elliott
Publisher: Oxford University Press
ISBN: 0199671397
Size: 22.37 MB
Format: PDF, ePub
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RNA plays a central, and until recently, somewhat underestimated role in the genetics underlying all forms of life on earth. This versatile molecule not only plays a crucial part in the synthesis of proteins from a DNA template, but is also intrinsically involved in the regulation of gene expression, and can even act as a catalyst in the form of a ribozyme. This latter property has led to the hypothesis that RNA - rather than DNA - could have played an essential part in the origin of life itself.

This landmark text provides a systematic overview of the exciting and rapidly moving field of RNA biology. Key pioneering experiments, which provided the underlying evidence for what we now know, are described throughout, while the relevance of the subject to human disease is highlighted via frequent boxes.

For the second edition of Molecular Biology of RNA, more introductory material has been incorporated at the beginning of the text, to aid students studying the subject for the first time. Throughout the text, new material has been included - particularly in relation to RNA binding domains, non-coding RNAs, and the connection between RNA biology and epigenetics. Finally, a new closing chapter discusses how exciting new technologies are being used to explore current topical areas of research.

Molecular Biology Of Rna

Author: David Elliott
Publisher: Oxford University Press
ISBN: 0199288372
Size: 67.84 MB
Format: PDF, ePub, Docs
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For many years, RNA was thought to have something of a supplementary role in genome function - an intermediate in the flow of biological information from gene to protein. In recent years, however, the centrality of RNA as a key player in gene expression has become clear; it is far from being merely a staging post between gene and protein. Instead, new insights into RNA structure and function have revolutionized our view of molecular biology, and the role of RNA in the evolution of life itself.

Molecular Biology of RNA is the first student text to provide a broad survey of RNA structure and function. It leads the reader through the life cycle of an RNA, placing particular emphasis on post-transcriptional events - including post-transcriptional processing and splicing - to reveal how hugely diverse gene products stem from a relatively modest gene pool. It also describes how RNA molecules have a range of biological functions beyond that of the messenger RNA, including roles as catalysts and regulatory molecules.

Throughout the book, descriptions of our current understanding of the field are augmented with examples of pioneer RNA researchers and their key experiments, demonstrating how we have reached our current level of understanding. Further, boxes illustrate the involvement of RNA in the aetiology of human disease, showing how an understanding of the molecular biology of RNA is central to understanding disease processes and their potential treatment.

Molecular Biology of RNA is an essential course text for molecular biology students in the 21st century, capturing the excitement of a field that has changed our understanding of genome function forever.

Online Resource Centre
The Online Resource Centre to accompany Molecular Biology of RNA features:

For registered adopters:
Figures from the book in electronic format

For students:
A hyperlinked bibliography of literature articles cited in the text

Molecular Biology

Author: David P. Clark BA (honors)Christ's College Cambridge 1973
PhD University of Brsitol (England) 1977
Publisher: Academic Cell
ISBN: 0123785898
Size: 13.18 MB
Format: PDF, Kindle
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Molecular Biology: Academic Cell Update provides an introduction to the fundamental concepts of molecular biology and its applications. It deliberately covers a broad range of topics to show that molecular biology is applicable to human medicine and health, as well as veterinary medicine, evolution, agriculture, and other areas. The present Update includes journal specific images and test bank. It also offers vocabulary flashcards.

The book begins by defining some basic concepts in genetics such as biochemical pathways, phenotypes and genotypes, chromosomes, and alleles. It explains the characteristics of cells and organisms, DNA, RNA, and proteins. It also describes genetic processes such as transcription, recombination and repair, regulation, and mutations. The chapters on viruses and bacteria discuss their life cycle, diversity, reproduction, and gene transfer. Later chapters cover topics such as molecular evolution; the isolation, purification, detection, and hybridization of DNA; basic molecular cloning techniques; proteomics; and processes such as the polymerase chain reaction, DNA sequencing, and gene expression screening.

  • Up to date description of genetic engineering, genomics, and related areas
  • Basic concepts followed by more detailed, specific applications
  • Hundreds of color illustrations enhance key topics and concepts
  • Covers medical, agricultural, and social aspects of molecular biology
  • Organized pedagogy includes running glossaries and keynotes (mini-summaries) to hasten comprehension

Rna Life S Indispensable Molecule

Author: James Darnell
Publisher: Cold Spring Harbor Laboratory Press
ISBN: 1936113198
Size: 73.64 MB
Format: PDF, Mobi
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In RNA: Life's Indispensable Molecule, Jim Darnell provides a comprehensive and captivating account of RNA research, illuminated by his own life-long and celebrated engagement in the field. Darnell describes how scientists unraveled fundamental questions about the biochemical and genetic importance of RNA--how mRNAs are generated and used to produce proteins, how noncoding and catalytic RNAs mediate key cellular processes, and how RNA molecules likely initiated life on Earth. With a scope extending from the early 20th century to the present day, and with the clarity expected from an accomplished textbook author, he conveys the intellectual context in which these questions first arose and explains how the key experiments were structured and answers obtained. The book is geared towards scientists from the graduate level on up, and will particularly appeal to active investigators in RNA biology, educators of molecular biology and biochemistry, and science historians.

Catalytic Rna Volume 120 Progress In Molecular Biology And Translational Science

Author:
Publisher: Academic Press
ISBN: 0123812860
Size: 24.22 MB
Format: PDF
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This special volume of Progress in Molecular Biology and Translational Science focuses on catalytic RNA. Written by experts in the field, the reviews cover a range of topics, from hammerhead ribozymes to spliceosome catalysis to Varkud satellite and hairpin ribozymes.
  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field

Rna Methods And Protocols Methods In Molecular Biology

Author:
Publisher: Humana Press
ISBN: 1588299139
Size: 51.16 MB
Format: PDF, Docs
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Recent insight into the transcripts generated from the mammalian genome (i.e. the transcriptome) has revealed that transcription is a far more complex phenomenon than previously thought. In RNA: Methods and Protocols, expert researchers provide the procedures and methods used to describe the structure of messenger RNAs and non-coding RNAs that are transcribed by RNA polymerase II as the immediate gene products in mammalian cells. Focused on the structure of the RNA products of “gene X” and the mapping of proteins associated with these RNAs, the volume presents appropriate information for non-specialists in RNA biology. Written in the highly successful Methods in Molecular Biology™ series format, many chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, RNA: Methods and Protocols views the transcriptional landscape with an appreciation for the role that proteins play in the processing and interpretation of genetic information in an attempt to further our crucial knowledge of the many products and sophisticated regulatory networks that result from it.

Rna Silencing Methods And Protocols Methods In Molecular Biology

Author:
Publisher: Humana Press
ISBN: 1588294366
Size: 37.88 MB
Format: PDF, Docs
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A collection of readily reproducible methods for the design, preparation, and use of RNAs for silencing gene expression in cells and organisms. The techniques range widely and include methods addressing the biochemical aspects of the silencing machinery, RNA silencing in non-mammalian organisms, and the in vivo delivery of siRNAs and silencing vectors. There are also techniques for designing, preparing, and using RNAs to silence gene expression, for fine-tuning regulation by targeting specific isoforms of a given gene, and for the study and use of microRNAs. The protocols follow the successful Methods in Molecular Biology™ series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.

Rna Mapping Methods And Protocols Methods In Molecular Biology

Author:
Publisher: Humana Press
ISBN: 1493910612
Size: 69.64 MB
Format: PDF
View: 5686
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In RNA Mapping- Methods and Protocols expert researchers in the field detail many of the methods which are now commonly used to study RNA. These include protocols for the consequence of the emerging interest in the characterization of cellular RNAs urged by their potential use as diagnostic biomarkers or therapeutic targets. In particular, the biological relevance of microRNAs in human physiology and disease development is highlighted in the 16 chapters focused on methods for their physical and functional mapping. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.

Authoritative and practical, RNA Mapping- Methods and Protocols provides instruction and inspiration for scientists who are facing the challenges of the discovery and/or functional characterization of RNA molecules for a wide variety of applications ranging from novel biomedical diagnostics to therapeutics and biomaterials.


Rna Vaccines Methods And Protocols Methods In Molecular Biology

Author:
Publisher: Humana Press
ISBN: 1493964798
Size: 44.44 MB
Format: PDF, Docs
View: 2892
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This volume provides an overview of the field and practical hints for vaccinologists in academia and industry. Chapters provide protocols on self-replicating RNA vectors, non-replication mRNA vectors, adjuvantation and delivery, and preclinical and clinical development. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

 Authoritative and cutting-edge, RNA Vaccines: Methods and Protocols aims to increased collaboration on RNA vaccines between basic and applied scientists in academia, government, and industry to develop future solutions for today’s challenges.



Bios Instant Notes In Molecular Biology

Author: Alexander McLennan
Publisher: Taylor & Francis
ISBN: 0415684161
Size: 30.94 MB
Format: PDF, ePub, Mobi
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Instant Notes in Molecular Biology, Fourth Edition is the perfect text for undergraduates looking for a concise introduction to the subject, or a study guide to use before examinations. Each topic begins with a summary of essential facts-an ideal revision checklist-followed by a description of the subject that focuses on core information, with clear, simple diagrams that are easy for students to understand and recall in essays and exams.


Molecular Biology Of Rna

Author: David Elliott
Publisher: Oxford University Press
ISBN: 019107103X
Size: 16.28 MB
Format: PDF, ePub, Mobi
View: 4134
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Introduction. to. Molecular. Biology. of. RNA. RNA-based processes are also
increasingly linked to the aetiology of ... science fiction during the 1970s and
1980s, at a time when molecular biology was already advancing by leaps and
bounds.

Molecular Biology Of The Cell

Author: Bruce Alberts
Publisher: Courier Corporation
ISBN: 9780824036959
Size: 69.56 MB
Format: PDF, ePub
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The book contains color illustrations and charts; and the included CD-ROM contains dozens of video clips, animations, molecular structures, and high-resolution micrographs. Annotation copyrighted by Book News Inc., Portland, OR.

Molecular Biology Of Rna Tumor Viruses

Author: John Stephenson
Publisher: Elsevier
ISBN: 0323146686
Size: 47.49 MB
Format: PDF, ePub
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This book will be of value both to graduate students and to established investigators with specific interest in other aspects of molecular biology.

Molecular Biology Of Rna

Author: Masayori Inouye
Publisher: Academic Press
ISBN: 1483273903
Size: 19.22 MB
Format: PDF, ePub, Docs
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An RNA acting as an enzyme, an RNA capable of self-splicing, and a branched
RNA covalently linked to DNA are a few ... working on the subject and will serve
as a useful guide to those about to start research in the molecular biology of RNA
.

Molecular Biology

Author: David P. Clark
Publisher: Elsevier
ISBN: 0123785944
Size: 23.30 MB
Format: PDF, ePub, Mobi
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The last quarter of the 20th century saw major scientific revolutions in genetics and computer technology. This book reflects this massive surge in our understanding of the molecular foundations of genetics.

Molecular Biology Of The Flavivirus

Author: Matthias Kalitzky
Publisher: Horizon Scientific Press
ISBN: 190493322X
Size: 71.28 MB
Format: PDF, ePub, Docs
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They cause approximately 70 different diseases which have a major impact on national economies and health authorities worldwide. This book reviews the most significant cutting edge discoveries in the flavivirus field.

Molecular Biology Of Rna Tumor Viruses

Author: John Stephenson
Publisher: Elsevier
ISBN: 0323146686
Size: 72.85 MB
Format: PDF, ePub, Mobi
View: 1994
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The authors of the individual chapters have attempted to present an overview of
the work in various areas pertaining to the molecular biology and biologic
significance Of RNA tumor viruses. A consideration of the historical background
of ...

The Molecular Biology Of Viruses

Author: John Colter
Publisher: Elsevier
ISBN: 0323142737
Size: 57.43 MB
Format: PDF, Kindle
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This book is of great benefit to biochemists, biophysicists, geneticists, microbiologists, and virologists.